IGF-1 Insulin-like Growth Factor

Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a protein that in humans is encoded by the IGF1 gene.[1][2] IGF-1 has also been referred to as a "sulfation factor"[3] and its effects were termed "non suppressible insulin-like activity" (NSILA) in the 1970s. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin, is used for the treatment of growth failure.[4] IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7,649 daltons.[5] GF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. Production is stimulated by growth hormone (GH) and can be retarded by undernutrition, growth hormone insensitivity, lack of growth hormone receptors, or failures of the downstream signalling pathway post GH receptor including SHP2 and STAT5B. Approximately 98% of IGF-1 is always bound to one of 6 binding proteins (IGF-BP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio.IGFBP-1 is regulated by insulin.[medical citation needed]

IGF-1 is produced throughout life. The highest rates of IGF-1 production occur during the pubertal growth spurt. The lowest levels occur in infancy and old age.[medical citation needed]

3-d model of IGF-1 Protein intake increases IGF-1 levels in humans, independent of total calorie consumption.[medical citation needed] Factors that are known to cause variation in the levels of growth hormone (GH) and IGF-1 in the circulation include: insulin levels, genetic make-up, the time of day, age, sex, exercise status, stress levels, nutrition level and body mass index (BMI), disease state, race, estrogen status and xenobiotic intake.[6] Fasting, including intermittent fasting, can reduce IGF-1 levels rapidly and dramatically.[medical citation needed] It may be, however, that fasting increases IGF-1 levels because fasting causes very low blood sugar, which in turn stimulates the release of growth hormone by the pituitary, [7] which in turn increaInsulin-like growth factor 1 (somatomedin C) SOURCE : Wikipedia

Knowledge management

Knowledge management (KM) is the process of capturing, developing, sharing, and effectively using organisational knowledge.[1] It refers to a multi-disciplined approach to achieving organisational objectives by making the best use of knowledge.[2] An established discipline since 1991 (see Nonaka 1991), KM includes courses taught in the fields of business administration, information systems, management, and library and information sciences (Alavi & Leidner 1999).[3][4] More recently, other fields have started contributing to KM research; these include information and media, computer science, public health, and public policy.[5] Columbia University, Kent State University and the University of Haifa offer dedicated Master of Science degrees in Knowledge Management.[6][7][8] Many large companies, public institutions and non-profit organisations have resources dedicated to internal KM efforts, often as a part of their business strategy, information technology, or human resource management departments.[9] Several consulting companies provide strategy and advice regarding KM to these organisations.[9] Knowledge management efforts typically focus on organisational objectives such as improved performance, competitive advantage, innovation, the sharing of lessons learned, integration and continuous improvement of the organisation.[10] KM efforts overlap with organisational learning and may be distinguished from that by a greater focus on the management of knowledge as a strategic asset and a focus on encouraging the sharing of knowledge.[2][11] It is an enabler of organisational learning. source: Wikipedia, the free encyclopedia

Latest Research Results on Cancer

Did you know the latest research results for the cause of cancer?

It says, it is not life style or genetic factors ,but it is biological bad luck.
Due to mutation of the cells.Read more here........

Most types of cancer can be put down to bad luck rather than risk factors such as smoking, a study has suggested.

A US team were trying to explain why some tissues were millions of times more vulnerable to cancer than others.

The results, in the journal Science, showed two thirds of the cancer types analysed were caused just by chance mutations rather than lifestyle.

However some of the most common and deadly cancers are still heavily influenced by lifestyle.

And Cancer Research UK said a healthy lifestyle would still heavily stack the odds in a person's favour.

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You’ve worked hard And your efforts have paid off  Congratulations! The president Brian Woosley!                   I can't wait without congratulating you on  this  day of  assuming duties as an honorable president of FanBox corporation at  your prime youth. A great person  attracts great people and knows how to hold them together.Wish You Good Luck and All the Best Wishes, for a peaceful  and successful career.          Jasha

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